CYP2D6 Genotype Phenotype Discordance Due to Drug-Drug Interaction.
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SUBMITTER: Monte AA
PROVIDER: S-EPMC6197912 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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CYP2D6 Genotype Phenotype Discordance Due to Drug-Drug Interaction.
Monte Andrew A AA West Kelsey K McDaniel Kyle T KT Flaten Hania K HK Saben Jessica J Shelton Shelby S Abdelmawla Farah F Bushman Lane R LR Williamson Kayla K Abbott Diana D Anderson Peter L PL
Clinical pharmacology and therapeutics 20180725 5
Drug-drug interactions have been demonstrated to alter cytochrome 2D6 (CYP2D6) enzyme phenotype due to inhibitor ingestion, although it is unclear how substrate interactions affect phenotype. This was a pragmatic clinical trial examining the kinetics of a CYP2D6 enzyme probe drug with and without CYP2D6-dependent substrates. Patients were enrolled into an inpatient study unit, and orally administered a 2 mg microdose of dextromethorphan (DM) to probe enzyme activity with and without CYP2D6-depen ...[more]
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