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Theta Phase-Coordinated Memory Reactivation Reoccurs in a Slow-Oscillatory Rhythm during NREM Sleep.

ABSTRACT: It has been proposed that sleep's contribution to memory consolidation is to reactivate prior encoded information. To elucidate the neural mechanisms carrying reactivation-related mnemonic information, we investigated whether content-specific memory signatures associated with memory reactivation during wakefulness reoccur during subsequent sleep. We show that theta oscillations orchestrate the reactivation of memories during both wakefulness and sleep. Reactivation patterns during sleep autonomously re-emerged at a rate of ?1 Hz, indicating a coordination by slow oscillatory activity.

SUBMITTER: Schreiner T

PROVIDER: S-EPMC6198287 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Theta Phase-Coordinated Memory Reactivation Reoccurs in a Slow-Oscillatory Rhythm during NREM Sleep.

Schreiner Thomas T Doeller Christian F CF Jensen Ole O Rasch Björn B Staudigl Tobias T

Cell reports 20181001 2

It has been proposed that sleep's contribution to memory consolidation is to reactivate prior encoded information. To elucidate the neural mechanisms carrying reactivation-related mnemonic information, we investigated whether content-specific memory signatures associated with memory reactivation during wakefulness reoccur during subsequent sleep. We show that theta oscillations orchestrate the reactivation of memories during both wakefulness and sleep. Reactivation patterns during sleep autonomo ...[more]

PMID: 30304670

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