Ontology highlight
ABSTRACT:
SUBMITTER: Carroll KR
PROVIDER: S-EPMC6198341 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Carroll Kaitlin R KR Elfers Eileen E EE Stevens Joseph J JJ McNally Jonathan P JP Hildeman David A DA Jordan Michael B MB Katz Jonathan D JD
Diabetes 20180813 11
Preserving endogenous insulin production is clinically advantageous and remains a vital unmet challenge in the treatment and reversal of type 1 diabetes. Although broad immunosuppression has had limited success in prolonging the so-called remission period, it comes at the cost of compromising beneficial immunity. Here, we used a novel strategy to specifically deplete the activated diabetogenic T cells that drive pathogenesis while preserving not only endogenous insulin production but also protec ...[more]