Ontology highlight
ABSTRACT:
SUBMITTER: Onuchic V
PROVIDER: S-EPMC6198826 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Onuchic Vitor V Lurie Eugene E Carrero Ivenise I Pawliczek Piotr P Patel Ronak Y RY Rozowsky Joel J Galeev Timur T Huang Zhuoyi Z Altshuler Robert C RC Zhang Zhizhuo Z Harris R Alan RA Coarfa Cristian C Ashmore Lillian L Bertol Jessica W JW Fakhouri Walid D WD Yu Fuli F Kellis Manolis M Gerstein Mark M Milosavljevic Aleksandar A
Science (New York, N.Y.) 20180823 6409
To assess the impact of genetic variation in regulatory loci on human health, we constructed a high-resolution map of allelic imbalances in DNA methylation, histone marks, and gene transcription in 71 epigenomes from 36 distinct cell and tissue types from 13 donors. Deep whole-genome bisulfite sequencing of 49 methylomes revealed sequence-dependent CpG methylation imbalances at thousands of heterozygous regulatory loci. Such loci are enriched for stochastic switching, which is defined as random ...[more]