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Renal transplantation in patients with Alport syndrome: patient selection, outcomes, and donor evaluation.

ABSTRACT: Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Because Alport syndrome is a genetic disorder, potential related donors must be carefully evaluated in order to minimize harm.

SUBMITTER: Kashtan CE 

PROVIDER: S-EPMC6198874 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Renal transplantation in patients with Alport syndrome: patient selection, outcomes, and donor evaluation.

Kashtan Clifford E CE  

International journal of nephrology and renovascular disease 20181016

Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Because Alport syndrome is a genetic disorder, potential related donors must be carefully evaluated in order to minimize harm. ...[more]