Unknown

Dataset Information

0

TIM-3, a promising target for cancer immunotherapy.


ABSTRACT: Patients with malignant tumor treated with immunotherapy have received significant clinical benefits over the years. Immune checkpoint blocking agents, such as anti-cytotoxic T-lymphocyte-associated protein-4 (anti-CTLA-4) and anti-programmed cell death protein-1 (anti-PD-1) monoclonal antibodies, have produced impressive clinical results in different types of cancer. T-cell immunoglobulin and mucin domain-3 (TIM-3), another immune checkpoint, could inhibit cancer immunity. Recent studies have highlighted that TIM-3 has an important role to play in T-cell exhaustion and correlates with the outcome of anti-PD-1 therapy. Targeting TIM-3 might be a promising approach for cancer immunotherapy. Here, we review the role of TIM-3 in cancer and clinical trials with TIM-3 inhibitors.

SUBMITTER: He Y 

PROVIDER: S-EPMC6198883 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

TIM-3, a promising target for cancer immunotherapy.

He Yayi Y   Cao Jie J   Zhao Chao C   Li Xuefei X   Zhou Caicun C   Hirsch Fred R FR  

OncoTargets and therapy 20181016


Patients with malignant tumor treated with immunotherapy have received significant clinical benefits over the years. Immune checkpoint blocking agents, such as anti-cytotoxic T-lymphocyte-associated protein-4 (anti-CTLA-4) and anti-programmed cell death protein-1 (anti-PD-1) monoclonal antibodies, have produced impressive clinical results in different types of cancer. T-cell immunoglobulin and mucin domain-3 (TIM-3), another immune checkpoint, could inhibit cancer immunity. Recent studies have h  ...[more]

Similar Datasets

| S-EPMC10576709 | biostudies-literature
| S-EPMC7793963 | biostudies-literature
| S-EPMC8235942 | biostudies-literature
| S-EPMC9515902 | biostudies-literature
| S-EPMC8174842 | biostudies-literature
| S-EPMC5372657 | biostudies-literature
| S-EPMC8863477 | biostudies-literature
| S-EPMC5356554 | biostudies-literature
| S-EPMC8088836 | biostudies-literature
| S-EPMC10788878 | biostudies-literature