Ontology highlight
ABSTRACT:
SUBMITTER: Lin XX
PROVIDER: S-EPMC6199276 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Lin Xin-Xuan XX Sen Ilke I Janssens Georges E GE Zhou Xin X Fonslow Bryan R BR Edgar Daniel D Stroustrup Nicholas N Swoboda Peter P Yates John R JR Ruvkun Gary G Riedel Christian G CG
Nature communications 20181023 1
The ability to perceive and respond to harmful conditions is crucial for the survival of any organism. The transcription factor DAF-16/FOXO is central to these responses, relaying distress signals into the expression of stress resistance and longevity promoting genes. However, its sufficiency in fulfilling this complex task has remained unclear. Using C. elegans, we show that DAF-16 does not function alone but as part of a transcriptional regulatory module, together with the transcription factor ...[more]