Ontology highlight
ABSTRACT:
SUBMITTER: Schneider JA
PROVIDER: S-EPMC6199279 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Schneider Jeffrey A JA Craven Timothy W TW Kasper Amanda C AC Yun Chi C Haugbro Michael M Briggs Erica M EM Svetlov Vladimir V Nudler Evgeny E Knaut Holger H Bonneau Richard R Garabedian Michael J MJ Kirshenbaum Kent K Logan Susan K SK
Nature communications 20181023 1
New chemical inhibitors of protein-protein interactions are needed to propel advances in molecular pharmacology. Peptoids are peptidomimetic oligomers with the capability to inhibit protein-protein interactions by mimicking protein secondary structure motifs. Here we report the in silico design of a macrocycle primarily composed of peptoid subunits that targets the β-catenin:TCF interaction. The β-catenin:TCF interaction plays a critical role in the Wnt signaling pathway which is over-activated ...[more]