Ontology highlight
ABSTRACT:
SUBMITTER: Lanoiselee Y
PROVIDER: S-EPMC6199324 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Lanoiselée Yann Y Moutal Nicolas N Grebenkov Denis S DS
Nature communications 20181023 1
Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid rearrangements of the medium constantly change the effective diffusivity felt locally by a diffusing particle and thus impact the distribution of the first-passage time to a reaction event. Here, we investigate the effect of these dynamic spatiotemporal heterogeneities onto diffusion-limited reactions. We describe a general mathematical fram ...[more]