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P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity.

ABSTRACT: Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key features and applications. Although this field of biomedical science is relatively young, these humanized mouse models have the potential to transform preclinical drug testing and eventually lead to a more cost-effective and rapid development of new therapies.

SUBMITTER: Bissig KD

PROVIDER: S-EPMC6199624 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity.

Bissig Karl-Dimiter KD Han Weiguo W Barzi Mercedes M Kovalchuk Nataliia N Ding Liang L Fan Xiaoyu X Pankowicz Francis P FP Zhang Qing-Yu QY Ding Xinxin X

Drug metabolism and disposition: the biological fate of chemicals 20180809 11

Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key fe ...[more]

PMID: 30093418

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