Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis.

ABSTRACT: BACKGROUND:The purpose of this study is to discuss whether genetic variants (rs2230199, rs1047286, rs2230205, and rs2250656) in the C3 gene account for a significant risk of advanced AMD. METHODS:We performed a meta-analysis using electronic databases to search relevant articles. A total of 40 case-control studies from 38 available articles (20,673 cases and 20,025 controls) were included in our study. RESULTS:In our meta-analysis, the pooled results showed that the carriage of G allele for rs2230199 and the T allele for rs1047286 had a tendency to the risk of advanced AMD (OR?=?1.49, 95% CI?=?1.39-1.59, P?

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6199710 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature