Bariatric surgery reduces CD36-bearing microvesicles of endothelial and monocyte origin.

ABSTRACT: Background:Bariatric surgery is a widely adopted treatment for obesity and its secondary complications. In the past decade, microvesicles (MVs) and CD36 have increasingly been considered as possible biomarkers for obesity, the metabolic syndrome (MetSy), type 2 diabetes mellitus (T2DM). Thus, the purpose of this study was to investigate how weight loss resulting from bariatric surgery affects levels of specific MV phenotypes and their expression of CD36 scavenger receptor. Additionally, we hypothesised that subjects with MetSy had higher baseline concentrations of investigated MV phenotypes. Methods:Twenty individuals undergoing Roux-en-Y gastric bypass surgery were evaluated before and 3 months after surgery. MVs were characterised by flow cytometry at both time points and defined as lactadherin-binding particles within a 100-1000 nm size gate. MVs of monocyte (CD14) and endothelial (CD62E) origin were defined by cell-specific markers, and their expression of CD36 was investigated. Results:Following bariatric surgery, subjects incurred an average BMI reduction (delta) of -?8.4?±?1.4 (p?

SUBMITTER: Botha J 

PROVIDER: S-EPMC6199798 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature