Adipsin, MIP-1b, and IL-8 as CSF Biomarker Panels for ALS Diagnosis.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that selectively attacks motor neurons in the brain and spinal cord. Despite important advances in the knowledge of the etiology and progression of the disease, there are still no solid grounds in which a clinician could make an early objective and reliable diagnosis from which patients could benefit. Diagnosis is difficult and basically made by clinical rating scales (ALSRs and El Escorial). The possible finding of biomarkers to aid in the early diagnosis and rate of disease progression could serve for future innovative therapeutic approaches. Recently, it has been suggested that ALS has an important immune component that could represent either the cause or the consequence of the disease. In this report, we an

SUBMITTER: Gonzalez-Garza MT 

PROVIDER: S-EPMC6199888 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature