Subanaesthetic ketamine and altered states of consciousness in humans.

ABSTRACT:

Background

Despite its designation as a 'dissociative anaesthetic,' the dissociative and psychoactive effects of ketamine remain incompletely understood. The goal of this study was to characterise the subjective experiences and accompanying EEG changes with subanaesthetic doses of ketamine.

Methods

High-density EEG was recorded in 15 human volunteers before, during, and after subanaesthetic ketamine infusion (0.5 mg kg^-1 over 40 min), with self-reported measures of altered states of consciousness obtained after ketamine exposure. Sensor- and source-level EEG changes were analysed with a focus on spectral power and regional changes.

Results

Ketamine-induced altered states were characterised predominantly by dissociative experiences such as disembodiment and

SUBMITTER: Vlisides PE 

PROVIDER: S-EPMC6200112 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature