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ABSTRACT:
SUBMITTER: Caulkins BG
PROVIDER: S-EPMC6200332 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Caulkins Bethany G BG Cervantes Silvia A SA Isas J Mario JM Siemer Ansgar B AB
The journal of physical chemistry. B 20181004 41
Intrinsically disordered protein domains not only are found in soluble proteins but also can be part of large protein complexes or protein aggregates. For example, several amyloid fibrils have intrinsically disordered domains framing a rigid β-sheet-rich core. These disordered domains can often be observed using solution NMR methods in combination with modest magic angle spinning and without perdeuteration. But how can these regions be detected using solution NMR methods when they are part of a ...[more]