Genetic divergence of HIV-1 B subtype in Italy over the years 2003-2016 and impact on CTL escape prevalence.
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ABSTRACT:
SUBMITTER: Alteri C
PROVIDER: S-EPMC6200748 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Genetic divergence of HIV-1 B subtype in Italy over the years 2003-2016 and impact on CTL escape prevalence.
Alteri Claudia C Fabeni Lavinia L Scutari Rossana R Berno Giulia G Di Carlo Domenico D Gori Caterina C Bertoli Ada A Vergori Alessandra A Mastrorosa Ilaria I Bellagamba Rita R Mussini Cristina C Colafigli Manuela M Montella Francesco F Pennica Alfredo A Mastroianni Claudio Maria CM Girardi Enrico E Andreoni Massimo M Antinori Andrea A Svicher Valentina V Ceccherini-Silberstein Francesca F Perno Carlo Federico CF Santoro Maria Mercedes MM
Scientific reports 20181024 1
HIV-1 is characterized by high genetic variability, with implications for spread, and immune-escape selection. Here, the genetic modification of HIV-1 B subtype over time was evaluated on 3,328 pol and 1,152 V3 sequences belonging to B subtype and collected from individuals diagnosed in Italy between 2003 and 2016. Sequences were analyzed for genetic-distance from consensus-B (Tajima-Nei), non-synonymous and synonymous rates (dN and dS), CTL escapes, and intra-host evolution over four time-spans ...[more]
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