Ontology highlight
ABSTRACT:
SUBMITTER: Nazer E
PROVIDER: S-EPMC6200757 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20181024 1
Increasing lines of evidence support that Argonaute2 (AGO2) harbors several nuclear functions in metazoa. In particular, Drosophila AGO2 modulates transcription of developmentally regulated genes; however, the molecular mechanisms behind AGO2 recruitment into chromatin and its function in transcription have not been deeply explored. In this study, we show that Drosophila AGO2 chromatin association depends on active transcription. In order to gain insight into how AGO2 controls transcription, we ...[more]