Ontology highlight
ABSTRACT:
SUBMITTER: Keniya MV
PROVIDER: S-EPMC6201081 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Keniya Mikhail V MV Sabherwal Manya M Wilson Rajni K RK Woods Matthew A MA Sagatova Alia A AA Tyndall Joel D A JDA Monk Brian C BC
Antimicrobial agents and chemotherapy 20181024 11
Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due to the emergence of drug-resistant fungal pathogens. We have addressed the need to improve the potency, spectrum, and specificity for azoles by expressing in <i>Saccharomyces cerevisiae</i> functional ...[more]