Ontology highlight
ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC6201105 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zhang Rui R Wu Fengbo F Wu Lei L Tian Yaomei Y Zhou Bailing B Zhang Xueyan X Huang Rong R Yu Chaoheng C He Gu G Yang Li L
Antimicrobial agents and chemotherapy 20181024 11
Owing to their broad-spectrum antibacterial properties, multitarget effects, and low drug resistance, antimicrobial peptides (AMPs) have played critical roles in the clinical therapy of drug-resistant bacterial infections. However, the potential hazard of hemolysis following systemic administration has greatly limited their application. Here, we developed a novel AMP derivative, DP7-C, by modifying a formerly identified highly active AMP (DP7) with cholesterol to form an amphiphilic conjugate. T ...[more]