Ontology highlight
ABSTRACT:
SUBMITTER: Tsai TH
PROVIDER: S-EPMC6201225 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Tsai Tsung-Huang TH Tam Kabik K Chen Shu-Fen SF Liou Jun-Yang JY Tsai Yi-Chen YC Lee Yen-Ming YM Huang Tai-Yu TY Shyue Song-Kun SK
Journal of cellular and molecular medicine 20180822 11
Acute hepatic injury caused by inflammatory liver disease is associated with high mortality. This study examined the role of caveolin-1 (Cav-1) in lipopolysaccharide (LPS) and D-galactosamine (GalN)-induced fulminant hepatic injury in wild type and Cav-1-null (Cav-1<sup>-/-</sup> ) mice. Hepatic Cav-1 expression was induced post-LPS/GalN treatment in wild-type mice. LPS/GalN-treated Cav-1<sup>-/-</sup> mice showed reduced lethality and markedly attenuated liver damage, neutrophil infiltration an ...[more]