Ontology highlight
ABSTRACT:
SUBMITTER: Cunha LD
PROVIDER: S-EPMC6201245 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Cunha Larissa D LD Yang Mao M Carter Robert R Guy Clifford C Harris Lacie L Crawford Jeremy C JC Quarato Giovanni G Boada-Romero Emilio E Kalkavan Halime H Johnson Michael D L MDL Natarajan Sivaraman S Turnis Meghan E ME Finkelstein David D Opferman Joseph T JT Gawad Charles C Green Douglas R DR
Cell 20180920 2
Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of cancer therapy. However, components of canonical autophagy play roles in other biological processes, adding complexity to this goal. One such alternative function of autophagy proteins is LC3-associated phagocytosis (LAP), which functions in phagosome maturation and subsequent signaling events. Here, we show that impairment of LAP in the myeloid compartment, rather than canonical autophagy, induces control ...[more]