PKC? replaces AMPK to regulate mitophagy: Another PEDF role on ischaemic cardioprotection.
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ABSTRACT:
SUBMITTER: Miao H
PROVIDER: S-EPMC6201373 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
PKCα replaces AMPK to regulate mitophagy: Another PEDF role on ischaemic cardioprotection.
Miao Haoran H Qiu Fan F Huang Bing B Liu Xiucheng X Zhang Hao H Liu Zhiwei Z Yuan Yanliang Y Zhao Qixiang Q Zhang Hu H Dong Hongyan H Zhang Zhongming Z
Journal of cellular and molecular medicine 20180919 11
Both decreased autophagy positive regulator AMP activated protein kinase (AMPK) level and promoted mitophagy are observed in oxygen-glucose deprivation (OGD) cardiomyocytes treated with pigment epithelium-derived factor (PEDF). This contradictory phenomenon and its underlying mechanisms have not been thoroughly elucidated. Our previous study reveals that PEDF increases the protein kinase Cα (PKCα) and phospho-PKCα (p-PKCα) contents to promote mitophagy. Thus, we investigated the association betw ...[more]
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