Ontology highlight
ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC6201501 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Wu Qi Q Sun Si S Li Zhiyu Z Yang Qian Q Li Bei B Zhu Shan S Wang Lijun L Wu Juan J Yuan Jingping J Yang Changhua C Li Juanjuan J Sun Shengrong S
Molecular cancer 20181025 1
Emerging evidence supports the pivotal roles of cancer-associated cachexia in breast cancer progression. However, the mediators and mechanisms that mediate cancer-induced cachexia remain unclear. Here, we show that breast cancer-derived exosomes alter adipocytes and muscle cells in terms of increased catabolism characterized by the release of metabolites. Likewise, tumour cells cocultivated with mature adipocytes or C2C12 exhibit an aggressive phenotype through inducing epithelial-mesenchymal tr ...[more]