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Relationship Between Symptomatic and Functional Improvement and Remission in a Treatment Response to Stimulant Trial.


ABSTRACT: OBJECTIVE:To evaluate the relationship between symptom and functional improvement and remission in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) enrolled in an 11-week open-label dose-optimization phase of an methylphenidate extended release (MPH-MLR) pivotal study. METHODS:Assessments included the Weiss Functional Impairment Rating Scale-Parent (WFIRS-P) and ADHD Rating Scale, Fourth Edition (ADHD-RS-IV). Definitions included the following: symptom improvement (?30% decrease in ADHD-RS-IV total score); symptom remission (ADHD-RS-IV total score ?18); functional improvement (decrease in WFIRS-P total score ?0.25 [minimally important difference]); and functional remission (WFIRS-P total score ?0.65). RESULTS:Two hundred children completed the open-label phase. At initial assessment, functional impairment was evident across all WFIRS-P domains and similar between children and adolescents. Those who were treatment naive had more functional impairment (WFIRS-P total: 0.82 vs. 0.70, p?=?0.02). Significant improvements in all WFIRS-P domains were noted at open-label end (p?

SUBMITTER: Weiss M 

PROVIDER: S-EPMC6201781 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Relationship Between Symptomatic and Functional Improvement and Remission in a Treatment Response to Stimulant Trial.

Weiss Margaret M   Childress Ann A   Mattingly Greg G   Nordbrock Earl E   Kupper Robert J RJ   Adjei Akwete L AL  

Journal of child and adolescent psychopharmacology 20180723 8


<h4>Objective</h4>To evaluate the relationship between symptom and functional improvement and remission in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) enrolled in an 11-week open-label dose-optimization phase of an methylphenidate extended release (MPH-MLR) pivotal study.<h4>Methods</h4>Assessments included the Weiss Functional Impairment Rating Scale-Parent (WFIRS-P) and ADHD Rating Scale, Fourth Edition (ADHD-RS-IV). Definitions included the following: symptom  ...[more]

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