Correction: Vibrotactile information improves proprioceptive reaching target localization.
Ontology highlight
ABSTRACT:
SUBMITTER: PLOS ONE Staff
PROVIDER: S-EPMC6201965 | biostudies-literature |
REPOSITORIES: biostudies-literature
Similar Datasets
Project description:Objective.Proprioceptive information provides individuals with a sense of our limb's static position and dynamic movement. Impaired or a lack of such feedback can diminish our ability to perform dexterous motions with our biological limbs or assistive devices. Here we seek to determine whether both static and dynamic components of proprioception can be recognized using variation of the spatial and temporal components of vibrotactile feedback.Approach.An array of five vibrotactors was placed on the forearm of each subject. Each tactor was encoded to represent one of the five forearm postures. Vibratory stimulus was elicited to convey the static position and movement of the forearm. Four experimental blocks were performed to test each subject's recognition of a forearm's simulated static position, rotational amplitude, rotational amplitude and direction, and rotational speed.Main results.Our results showed that the subjects were able to perform proprioceptive recognition based on the delivered vibrotactile information. Specifically, rotational amplitude recognition resulted in the highest level of accuracy (99.0%), while the recognition accuracy of the static position and the rotational amplitude-direction was the lowest (91.7% and 90.8%, respectively). Nevertheless, all proprioceptive properties were perceived with >90% accuracy, indicating that the implemented vibrotactile encoding scheme could effectively provide proprioceptive information to the users.Significance.The outcomes suggest that information pertaining to static and dynamic aspects of proprioception can be accurately delivered using an array of vibrotactors. This feedback approach could be used to potentially evaluate the sensorimotor integration processes during human-machine interactions, and to improve sensory feedback in clinical populations with somatosensory impairments.
| S-EPMC8715509 | biostudies-literature
Project description:Difficulties with visual perspective-taking among individuals with autism spectrum disorders remain poorly understood. Many studies have presumed that first-person visual input can be mentally transformed to a third-person perspective during visual perspective-taking tasks; however, existing research has not fully revealed the computational strategy used by those with autism spectrum disorders for taking another person's perspective. In this study, we designed a novel approach to test a strategy using the opposite-directional effect among children with autism spectrum disorders. This effect refers to how a third-person perspective as a visual input alters a cognitive process. We directly manipulated participants' visual perspective by placing a camera at different positions; participants could watch themselves from a third-person perspective during a reaching task with no endpoint feedback. During a baseline task, endpoint bias (with endpoint feedback but no visual transformation) did not differ significantly between groups. However, the endpoint was affected by extrinsic coordinate information in the control group relative to the autism spectrum disorders group when the visual perspective was transformed. These results indicate an increased reliance on proprioception during the reaching task with perspective manipulation in the autism spectrum disorders group.
| S-EPMC8342420 | biostudies-literature
Project description:The neurobiology of reaching has been extensively studied in human and non-human primates. However, the mechanisms that allow a subject to decide-without engaging in explicit action-whether an object is reachable are not fully understood. Some studies conclude that decisions near the reach limit depend on motor simulations of the reaching movement. Others have shown that the body schema plays a role in explicit and implicit distance estimation, especially after motor practice with a tool. In this study we evaluate the causal role of multisensory body representations in the perception of reachable space. We reasoned that if body schema is used to estimate reach, an illusion of the finger size induced by proprioceptive stimulation should propagate to the perception of reaching distances. To test this hypothesis we induced a proprioceptive illusion of extension or shrinkage of the right index finger while participants judged a series of LEDs as reachable or non-reachable without actual movement. Our results show that reach distance estimation depends on the illusory perceived size of the finger: illusory elongation produced a shift of reaching distance away from the body whereas illusory shrinkage produced the opposite effect. Combining these results with previous findings, we suggest that deciding if a target is reachable requires an integration of body inputs in high order multisensory parietal areas that engage in movement simulations through connections with frontal premotor areas.
| S-EPMC4482541 | biostudies-literature
Project description:BackgroundPassive robot-generated arm movements in conjunction with proprioceptive decision making and feedback modulate functional connectivity (FC) in sensory motor networks and improve sensorimotor adaptation in normal individuals. This proof-of-principle study investigates whether these effects can be observed in stroke patients.MethodsA total of 10 chronic stroke patients with a range of stable motor and sensory deficits (Fugl-Meyer Arm score [FMA] 0-65, Nottingham Sensory Assessment [NSA] 10-40) underwent resting-state functional magnetic resonance imaging before and after a single session of robot-controlled proprioceptive training with feedback. Changes in FC were identified in each patient using independent component analysis as well as a seed region-based approach. FC changes were related to impairment and changes in task performance were assessed.ResultsA single training session improved average arm reaching accuracy in 6 and proprioception in 8 patients. Two networks showing training-associated FC change were identified. Network C1 was present in all patients and network C2 only in patients with FM scores >7. Relatively larger C1 volume in the ipsilesional hemisphere was associated with less impairment ( r = 0.83 for NSA, r = 0.73 for FMA). This association was driven by specific regions in the contralesional hemisphere and their functional connections (supramarginal gyrus with FM scores r = 0.82, S1 with NSA scores r = 0.70, and cerebellum with NSA score r = -0.82).ConclusionA single session of robot-controlled proprioceptive training with feedback improved movement accuracy and induced FC changes in sensory motor networks of chronic stroke patients. FC changes are related to functional impairment and comprise bilateral sensory and motor network nodes.
| S-EPMC6389407 | biostudies-literature
Project description:Familial dysautonomia (FD) is a recessive neurodegenerative disease caused by a splice mutation in Elongator complex protein 1 (ELP1, also known as IKBKAP) which leads to variable skipping of exon 20 and to a drastic reduction of ELP1 levels in the nervous system. Clinically, many of the debilitating aspects of the disease are related to a progressive loss of proprioception, which leads to severe gait ataxia, spinal deformities and respiratory insufficiency due to neuromuscular incoordination. There is currently no effective treatment for FD and the disease is ultimately fatal. Development of a drug that targets the underlying molecular defect provides hope that the drastic peripheral neurodegeneration characteristic of FD can be halted. We demonstrate herein that the FD mouse, TgFD9; IkbkapΔ20/flox, recapitulates the proprioceptive impairment observed in individuals with FD, and we provide the in vivo evidence that postnatal correction of mutant ELP1 splicing promoted by the small molecule kinetin can rescue neurological phenotypes in FD. Daily administration of kinetin starting at birth improves sensory-motor coordination and prevents the onset of spinal abnormalities by stopping the loss of proprioceptive neurons. These phenotypic improvements correlate with increased levels of full length ELP1 mRNA and protein in multiple tissues including the peripheral nervous system (PNS). Our results show that postnatal correction of the underlying ELP1 splicing defect can rescue devastating disease phenotypes and is therefore a viable therapeutic approach for persons with FD.
2019-03-21 | GSE126155 | GEO
Project description:ObjectivesTuberculosis (TB) control in schools is a concern in low-income and middle-income countries with high TB burdens. TB knowledge is recognised as important for TB control in China, which has one of the highest TB prevalence in the world. Accordingly, National TB Control Guideline in China emphasised TB-health education in schools as one of the core strategies for improving TB knowledge among the population. It was important to assess the level of TB knowledge in schools following 5-year implementation of the guideline, to determine whether the information was reaching the targets.DesignA cross-sectional study.Methods and study settingThis survey assessed TB knowledge and access to TB-health information by questionnaire survey with 1486 undergraduates from two medical universities in Southwest China.ResultsOverall, the students had inadequate TB knowledge. Only 24.1%, 27.2% and 34.1% of the students had knowledge of TB symptoms of cough/blood-tinged sputum, their local TB dispensaries and free TB treatment policy, respectively. Very few (14.5%) had heard about the Directly Observed Therapy Short Course (DOTS), and only about half (54%) had ever accessed TB-health education information. Exposure to health education messages was significantly associated with increased knowledge of the five core TB knowledge as follows: classic TB symptoms of cough/blood-tinged sputum (OR (95% CI) 0.5(0.4 to 0.7)), TB modes of transmission (OR (95% CI) 0.4(0.3 to 0.5)), curability of TB (OR (95% CI) 0.6(0.5 to 0.7)), location and services provided by TB local dispensaries (OR (95% CI) 0.6(0.5 to 0.8)) and the national free TB treatment policy (OR (95% CI) 0.7(0.5 to 0.8)).ConclusionsThe findings pose the question of whether it is time for a rethink of the current national and global approach to TB-health education/promotion which favours promotion of awareness on World TB Days rather than regular community sensitisation efforts.
| S-EPMC3780336 | biostudies-literature
Project description:Familial dysautonomia (FD) is a recessive neurodegenerative disease caused by a splice mutation in Elongator complex protein 1 (ELP1, also known as IKBKAP); this mutation leads to variable skipping of exon 20 and to a drastic reduction of ELP1 in the nervous system. Clinically, many of the debilitating aspects of the disease are related to a progressive loss of proprioception; this loss leads to severe gait ataxia, spinal deformities, and respiratory insufficiency due to neuromuscular incoordination. There is currently no effective treatment for FD, and the disease is ultimately fatal. The development of a drug that targets the underlying molecular defect provides hope that the drastic peripheral neurodegeneration characteristic of FD can be halted. We demonstrate herein that the FD mouse TgFD9;Ikbkap?20/flox recapitulates the proprioceptive impairment observed in individuals with FD, and we provide the in vivo evidence that postnatal correction, promoted by the small molecule kinetin, of the mutant ELP1 splicing can rescue neurological phenotypes in FD. Daily administration of kinetin starting at birth improves sensory-motor coordination and prevents the onset of spinal abnormalities by stopping the loss of proprioceptive neurons. These phenotypic improvements correlate with increased amounts of full-length ELP1 mRNA and protein in multiple tissues, including in the peripheral nervous system (PNS). Our results show that postnatal correction of the underlying ELP1 splicing defect can rescue devastating disease phenotypes and is therefore a viable therapeutic approach for persons with FD.
| S-EPMC6451698 | biostudies-literature
Project description:The performance of gene expression microarrays has been well characterized using controlled reference samples, but the performance on clinical samples remains less clear. We identified sources of technical bias affecting many genes in concert, thus causing spurious correlations in clinical data sets and false associations between genes and clinical variables. We developed a method to correct for technical bias in clinical microarray data, which increased concordance with known biological relationships in multiple data sets.
| S-EPMC2374720 | biostudies-literature
Project description:Reaching toward a visual target involves at least two sources of information. One is the visual feedback from the hand as it approaches the target. Another is proprioception from the moving limb, which informs the brain of the location of the hand relative to the target even when the hand is not visible. Where these two sources of information are represented in the human brain is unknown. In the present study, we investigated the cortical representations for reaching with or without visual feedback from the moving hand, using functional magnetic resonance imaging. To identify reach-dominant areas, we compared reaching with saccades. Our results show that a reach-dominant region in the anterior precuneus (aPCu), extending into medial intraparietal sulcus, is equally active in visual and nonvisual reaching. A second region, at the superior end of the parieto-occipital sulcus (sPOS), is more active for visual than for nonvisual reaching. These results suggest that aPCu is a sensorimotor area whose sensory input is primarily proprioceptive, while sPOS is a visuomotor area that receives visual feedback during reaching. In addition to the precuneus, medial, anterior intraparietal, and superior parietal cortex were also activated during both visual and nonvisual reaching, with more anterior areas responding to hand movements only and more posterior areas responding to both hand and eye movements. Our results suggest that cortical networks for reaching are differentially activated depending on the sensory conditions during reaching. This indicates the involvement of multiple parietal reach regions in humans, rather than a single homogenous parietal reach region.
| S-EPMC3407568 | biostudies-literature
Project description:In this paper, we propose a deep reinforcement learning-based framework that enables adaptive and continuous control of a robot to push unseen objects from random positions to the target position. Our approach takes into account contact information in the design of the reward function, resulting in improved success rates, generalization for unseen objects, and task efficiency compared to policies that do not consider contact information. Through reinforcement learning using only one object in simulation, we obtain a learned policy for manipulating a single object, which demonstrates good generalization when applied to the task of pushing unseen objects. Finally, we validate the effectiveness of our approach in real-world scenarios.
| S-EPMC10536165 | biostudies-literature