Second signals rescue B cells from activation-induced mitochondrial dysfunction and death.
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ABSTRACT:
SUBMITTER: Akkaya M
PROVIDER: S-EPMC6202187 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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Second signals rescue B cells from activation-induced mitochondrial dysfunction and death.
Akkaya Munir M Traba Javier J Roesler Alexander S AS Miozzo Pietro P Akkaya Billur B Theall Brandon P BP Sohn Haewon H Pena Mirna M Smelkinson Margery M Kabat Juraj J Dahlstrom Eric E Dorward David W DW Skinner Jeff J Sack Michael N MN Pierce Susan K SK
Nature immunology 20180709 8
B cells are activated by two temporally distinct signals, the first provided by the binding of antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells. Here we found that B cells responded to antigen by rapidly increasing their metabolic activity, including both oxidative phosphorylation and glycolysis. In the absence of a second signal, B cells progressively lost mitochondrial function and glycolytic capacity, which led to apoptosis. Mitochondrial dysfunction was ...[more]
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