Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis.

ABSTRACT: Prostaglandin E2 (PGE₂ ) plays a critical role in intestinal mucosal tolerance and barrier integrity. Cyclooxygenase-2 (COX-2)-dependent PGE₂ production involves mobilisation of arachidonic acid. Lactobacillus rhamnosus GG (LbGG) is one of the most widely used probiotics reported to colonise the colonic mucosa. LbGG contributes to the protection of the small intestine against radiation injury through the repositioning of mucosal COX-2 expressing cells. However, it is unknown if LbGG modulates PGE₂ production in the colonic mucosa under homeostasis and the major cellular elements involved in these processes. Colonic epithelial and CD90⁺ mesenchymal stromal cells, also known as (myo) fibroblasts (CMFs), are abundant innate immune cells in normal co

SUBMITTER: Uribe G 

PROVIDER: S-EPMC6202218 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature