Ontology highlight
ABSTRACT:
SUBMITTER: Nowak RP
PROVIDER: S-EPMC6202246 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature chemical biology 20180611 7
Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality. However, we currently lack a detailed understanding of the molecular basis for target recruitment and selectivity, which is critically required to enable rational design of degraders. Here we utilize a comprehensive characterization of the ligand-dependent CRBN-BRD4 interaction to demonstrate that binding between pro ...[more]