Ontology highlight
ABSTRACT:
SUBMITTER: Mosaei H
PROVIDER: S-EPMC6202310 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Mosaei Hamed H Molodtsov Vadim V Kepplinger Bernhard B Harbottle John J Moon Christopher William CW Jeeves Rose Elizabeth RE Ceccaroni Lucia L Shin Yeonoh Y Morton-Laing Stephanie S Marrs Emma Claire Louise ECL Wills Corinne C Clegg William W Yuzenkova Yulia Y Perry John David JD Bacon Joanna J Errington Jeff J Allenby Nicholas Edward Ellis NEE Hall Michael John MJ Murakami Katsuhiko S KS Zenkin Nikolay N
Molecular cell 20180920 2
Antibiotic-resistant bacterial pathogens pose an urgent healthcare threat, prompting a demand for new medicines. We report the mode of action of the natural ansamycin antibiotic kanglemycin A (KglA). KglA binds bacterial RNA polymerase at the rifampicin-binding pocket but maintains potency against RNA polymerases containing rifampicin-resistant mutations. KglA has antibiotic activity against rifampicin-resistant Gram-positive bacteria and multidrug-resistant Mycobacterium tuberculosis (MDR-M. tu ...[more]