Ontology highlight
ABSTRACT:
SUBMITTER: Piebalgs A
PROVIDER: S-EPMC6202379 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20181025 1
Ischaemic stroke can occur when an artery to the brain is blocked by a blood clot. The use of thrombolytic agents, such as tissue plasminogen activator (tPA), to dissolve the occluding clot is limited by the risk of intracerebral haemorrhage (ICH), a known side effect associated with tPA. We developed a computational thrombolysis model for a 3D patient-specific artery coupled with a compartmental model for temporal concentrations of tPA and lysis proteins during intravenous infusion of tPA, in o ...[more]