Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling.
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ABSTRACT:
SUBMITTER: Rahman A
PROVIDER: S-EPMC6202469 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Importance of Feedback and Feedforward Loops to Adaptive Immune Response Modeling.
Rahman Anisur A Tiwari Abhinav A Narula Jatin J Hickling Timothy T
CPT: pharmacometrics & systems pharmacology 20180930 10
The human adaptive immune system is a very complex network of different types of cells, cytokines, and signaling molecules. This complex network makes it difficult to understand the system level regulations. To properly explain the immune system, it is necessary to explicitly investigate the presence of different feedback and feedforward loops (FFLs) and their crosstalks. Considering that these loops increase the complexity of the system, the mathematical modeling has been proved to be an import ...[more]
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