Perspective on the State of Pharmacometrics and Systems Pharmacology Integration.
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ABSTRACT:
SUBMITTER: Trame MN
PROVIDER: S-EPMC6202472 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Perspective on the State of Pharmacometrics and Systems Pharmacology Integration.
Trame Mirjam N MN Riggs Matthew M Biliouris Konstantinos K Marathe Dhananjay D Mettetal Jerome J Post Teun M TM Rizk Matthew L ML Visser Sandra A G SAG Musante Cynthia J CJ
CPT: pharmacometrics & systems pharmacology 20180821 10
Reliance on modeling and simulation in drug discovery and development has dramatically increased over the past decade. Two disciplines at the forefront of this activity, pharmacometrics and systems pharmacology (SP), emerged independently from different fields; consequently, a perception exists that only few examples integrate these approaches. Herein, we review the state of pharmacometrics and SP integration and describe benefits of combining these approaches in a model-informed drug discovery ...[more]
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