Ontology highlight
ABSTRACT:
SUBMITTER: Hanke N
PROVIDER: S-EPMC6202474 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Hanke Nina N Frechen Sebastian S Moj Daniel D Britz Hannah H Eissing Thomas T Wendl Thomas T Lehr Thorsten T
CPT: pharmacometrics & systems pharmacology 20180907 10
According to current US Food and Drug Administration (FDA) and European Medicines Agency (EMA) guidance documents, physiologically based pharmacokinetic (PBPK) modeling is a powerful tool to explore and quantitatively predict drug-drug interactions (DDIs) and may offer an alternative to dedicated clinical trials. This study provides whole-body PBPK models of rifampicin, itraconazole, clarithromycin, midazolam, alfentanil, and digoxin within the Open Systems Pharmacology (OSP) Suite. All models w ...[more]