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Estrogen induces cell proliferation by promoting ABCG2-mediated efflux in endometrial cancer cells.


ABSTRACT: Recently, it has reported that overeating of lipid-food has led to increase the amount of estrogen in vivo and the incidence of endometrial carcinomas. It is well-known that ATP-binding cassette transporter sub-family G2 (ABCG2) is highly expressed in cancer stem cells (CSCs). CSCs possess the ability for differentiation, tumorigenesis, stem cell self-renewal, and the efflux of anti-cancer drug and these abilities affect malignancy of cancer cells. However, little is known about the relationship between the expression of ABCG2 and malignancy of cancer cells. The present study aimed at understanding the regulatory mechanism underlying 17-?-estradiol (E2)-induced cell proliferation under the control of ABCG2. E2 increased cell viability with a peak at 1??M and facilitated ABCG2 mRNA expression followed by the increase of ABCG2 expression level at plasma membrane. E2-induced cell proliferation was inhibited by reserpine, an inhibitor of ABCG2, and the ABCG2 siRNA treatment. Thus, these results imply that ABCG2 plays an important role in the promotion of E2-induced cell proliferation in Ishikawa cells.

SUBMITTER: Yaguchi T 

PROVIDER: S-EPMC6202658 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Estrogen induces cell proliferation by promoting ABCG2-mediated efflux in endometrial cancer cells.

Yaguchi Takahiro T   Onishi Takafumi T  

Biochemistry and biophysics reports 20181023


Recently, it has reported that overeating of lipid-food has led to increase the amount of estrogen in vivo and the incidence of endometrial carcinomas. It is well-known that ATP-binding cassette transporter sub-family G2 (ABCG2) is highly expressed in cancer stem cells (CSCs). CSCs possess the ability for differentiation, tumorigenesis, stem cell self-renewal, and the efflux of anti-cancer drug and these abilities affect malignancy of cancer cells. However, little is known about the relationship  ...[more]

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