Ontology highlight
ABSTRACT:
SUBMITTER: Dunn-Pirio AM
PROVIDER: S-EPMC6202665 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Dunn-Pirio Anastasie M AM Woodring Sarah S Lipp Eric E Herndon James E JE Healy Patrick P Weant Mallika M Randazzo Dina D Desjardins Annick A Friedman Henry S HS Peters Katherine B KB
Epilepsy & behavior case reports 20181009
Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy. We conducted a single-arm study of adjunctive perampanel for patients with focal-onset glioma-associated seizures. The most common related adverse events were fatigue and dizziness. Three out of 8 participants had self-reported seizure reduction and an add ...[more]