Unknown

Dataset Information

0

Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: Dose-efficacy studies upon oral administration.


ABSTRACT: Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), is a viral hemorrhagic fever with a high case fatality rate. Favipiravir was reported to be effective in the treatment of SFTSV infection in vivo in type I interferon receptor knockout (IFNAR-/-) mice at treatment dosages of both 60 mg/kg/day and 300 mg/kg/day for a duration of 5 days. In this study, the efficacy of favipiravir at dosages of 120 mg/kg/day and 200 mg/kg/day against SFTSV infection in an IFNAR-/- mouse infection model was investigated. IFNAR-/- mice were subcutaneously infected with SFTSV at a 1.0 × 10(6) 50% tissue culture infectious dose followed by twice daily administration of favipiravir, comprising a total dose of either 120 mg/kg/day or 200 mg/kg/day. The treatment was initiated either immediately post infection or at predesignated time points post infection. Neutralizing antibodies in the convalescent-phase mouse sera was examined by the pseudotyped VSV system. All mice treated with favipiravir at dosages of 120 mg/kg/day or 200 mg/kg/day survived when the treatment was initiated at no later than 4 days post infection. A decrease in body weight of mice was observed when the treatment was initiated at 3-4 days post infection. Furthermore, all control mice died. The body weight of mice did not decrease when treatment with favipiravir was initiated immediately post infection at dosages of 120 mg/kg/day and 200 mg/kg/day. Neutralizing antibodies were detected in the convalescent-phase mouse sera. Similar to the literature-reported peritoneal administration of favipiravir at 300 mg/kg/day, the oral administration of favipiravir at dosages of 120 mg/kg/day and 200 mg/kg/day to IFNAR-/- mice infected with SFTSV was effective.

SUBMITTER: Tani H 

PROVIDER: S-EPMC6203377 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: Dose-efficacy studies upon oral administration.

Tani Hideki H   Komeno Takashi T   Fukuma Aiko A   Fukushi Shuetsu S   Taniguchi Satoshi S   Shimojima Masayuki M   Uda Akihiko A   Morikawa Shigeru S   Nakajima Nozomi N   Furuta Yousuke Y   Saijo Masayuki M  

PloS one 20181026 10


Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), is a viral hemorrhagic fever with a high case fatality rate. Favipiravir was reported to be effective in the treatment of SFTSV infection in vivo in type I interferon receptor knockout (IFNAR-/-) mice at treatment dosages of both 60 mg/kg/day and 300 mg/kg/day for a duration of 5 days. In this study, the efficacy of favipiravir at dosages of 120 mg/kg/day and 200 mg/kg/day against SFTSV infection in an IFNAR-/- mou  ...[more]

Similar Datasets

| S-EPMC6700174 | biostudies-literature
| S-EPMC7223615 | biostudies-literature
| S-EPMC8479638 | biostudies-literature
| S-EPMC10699656 | biostudies-literature
2018-10-30 | GSE121911 | GEO
| S-EPMC10617428 | biostudies-literature
| S-EPMC6658772 | biostudies-literature
| S-EPMC6548318 | biostudies-literature
| S-EPMC6610197 | biostudies-literature
2022-10-13 | PXD033989 | Pride