Social stress during adolescence activates long-term microglia inflammation insult in reward processing nuclei.
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ABSTRACT:
SUBMITTER: Rodriguez-Arias M
PROVIDER: S-EPMC6203396 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Social stress during adolescence activates long-term microglia inflammation insult in reward processing nuclei.
Rodríguez-Arias Marta M Montagud-Romero Sandra S Guardia Carrión Ana María AM Ferrer-Pérez Carmen C Pérez-Villalba Ana A Marco Eva E López Gallardo Meritxell M Viveros María-Paz MP Miñarro José J
PloS one 20181026 10
The experience of social stress during adolescence is associated with higher vulnerability to drug use. Increases in the acquisition of cocaine self-administration, in the escalation of cocaine-seeking behavior, and in the conditioned rewarding effects of cocaine have been observed in rodents exposed to repeated social defeat (RSD). In addition, prolonged or severe stress induces a proinflammatory state with microglial activation and increased cytokine production. The aim of the present work was ...[more]
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