Ontology highlight
ABSTRACT:
SUBMITTER: Castiglione GM
PROVIDER: S-EPMC6203435 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Castiglione Gianni M GM Chang Belinda Sw BS
eLife 20181026
Trade-offs between protein stability and activity can restrict access to evolutionary trajectories, but widespread epistasis may facilitate indirect routes to adaptation. This may be enhanced by natural environmental variation, but in multicellular organisms this process is poorly understood. We investigated a paradoxical trajectory taken during the evolution of tetrapod dim-light vision, where in the rod visual pigment rhodopsin, E122 was fixed 350 million years ago, a residue associated with i ...[more]