Association of ERAP1 gene polymorphisms with the susceptibility to psoriasis vulgaris: A case-control study.

ABSTRACT: Psoriasis vulgaris (PsV), also known as plaque psoriasis, is a life-threatening autoimmune skin disease. Inflammatory factors may contribute to the development of PsV. Present study aimed to explore the association of endoplasmic reticulum aminopeptidase 1 (ERAP1) gene polymorphisms (rs26653 and rs27524) with PsV susceptibility in a Chinese Han population. Subgroup analysis was also performed based on the onset of PsV.Present case-control study included 143 patients with PsV and 149 healthy controls. Direct sequencing method was used for genotyping ERAP1 polymorphisms. Chi-squared test was used to estimate the association between ERAP1 polymorphisms and PsV susceptibility. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess association strength.The polymorphism rs26653 was positively correlated with PsV susceptibility (CC vs GG, P?=?.047, OR?=?1.964, 95% CI?=?1.006-3.834; C vs G, P?=?.042, OR?=?1.403, 95% CI?=?1.011-1.946). Meanwhile, its CC genotype and C allele were positively associated with the early onset of PsV (P?=?.036, OR?=?2.080, 95% CI?=?1.044-4.145; P?=?.034, OR?=?1.443, 95% CI?=?1.028-2.024) and increased PsV risk in the subgroup with family history (P?=?.029, OR?=?2.149, 95% CI?=?1.075-4.296; P?=?.027, OR?=?1.466, 95% CI?=?1.044-2.059).ERAP1 gene rs26653 polymorphism may increase the risk of PsV in Chinese Han population.

SUBMITTER: Fu Y 

PROVIDER: S-EPMC6203476 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature