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Diffuse optical spectroscopy for monitoring the responses of patients with breast cancer to neoadjuvant chemotherapy: A meta-analysis.


ABSTRACT:

Background

This study aimed to investigate the potential of diffuse optical spectroscopy (DOT) for monitoring the responses of patients with breast cancer to neoadjuvant chemotherapy (NAC).

Methods

We searched PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Web of Science for relevant studies. Data were extracted for pooled analysis, heterogeneity testing, threshold effect testing, sensitivity analysis, publication bias analysis, and subgroup analysis.

Results

The pooled meta-analysis of the 10 eligible studies that included 422 patients indicated the high performance of DOT for monitoring total patient responses to NAC (OR?=?14.78, 95% CI: 8.23-26.54, P?ConclusionOur meta-analysis of available published data indicated that DOT can be potentially used to predict and monitor patient responses to NAC. A larger study population is needed to fully assess the use of DOT for guiding therapies and predicting responses of individual subjects to NAC.

SUBMITTER: Liu YH 

PROVIDER: S-EPMC6203577 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

Diffuse optical spectroscopy for monitoring the responses of patients with breast cancer to neoadjuvant chemotherapy: A meta-analysis.

Liu Yong Hong YH   Xue Ling Bo LB   Yang Yan Fang YF   Zhao Tian Jiao TJ   Bai Yang Y   Zhang Bu Yong BY   Li Jie J  

Medicine 20181001 41


<h4>Background</h4>This study aimed to investigate the potential of diffuse optical spectroscopy (DOT) for monitoring the responses of patients with breast cancer to neoadjuvant chemotherapy (NAC).<h4>Methods</h4>We searched PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Web of Science for relevant studies. Data were extracted for pooled analysis, heterogeneity testing, threshold effect testing, sensitivity analysis, publication bias analysis, and subgroup analysis.<h4>Results</h4>  ...[more]

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