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ABSTRACT: Background
This study aimed to investigate the potential of diffuse optical spectroscopy (DOT) for monitoring the responses of patients with breast cancer to neoadjuvant chemotherapy (NAC).Methods
We searched PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Web of Science for relevant studies. Data were extracted for pooled analysis, heterogeneity testing, threshold effect testing, sensitivity analysis, publication bias analysis, and subgroup analysis.Results
The pooled meta-analysis of the 10 eligible studies that included 422 patients indicated the high performance of DOT for monitoring total patient responses to NAC (OR?=?14.78, 95% CI: 8.23-26.54, P?ConclusionOur meta-analysis of available published data indicated that DOT can be potentially used to predict and monitor patient responses to NAC. A larger study population is needed to fully assess the use of DOT for guiding therapies and predicting responses of individual subjects to NAC.
SUBMITTER: Liu YH
PROVIDER: S-EPMC6203577 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Liu Yong Hong YH Xue Ling Bo LB Yang Yan Fang YF Zhao Tian Jiao TJ Bai Yang Y Zhang Bu Yong BY Li Jie J
Medicine 20181001 41
<h4>Background</h4>This study aimed to investigate the potential of diffuse optical spectroscopy (DOT) for monitoring the responses of patients with breast cancer to neoadjuvant chemotherapy (NAC).<h4>Methods</h4>We searched PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Web of Science for relevant studies. Data were extracted for pooled analysis, heterogeneity testing, threshold effect testing, sensitivity analysis, publication bias analysis, and subgroup analysis.<h4>Results</h4> ...[more]