Dataset Information

Risk of regorafenib-induced cardiovascular events in patients with solid tumors: A systematic review and meta-analysis.

ABSTRACT:

Background

The present comparative meta-analysis was conducted to evaluate the cardiovascular events of regorafenib in patients with solid tumors.

Methods

Eligible studies from MEDLINE, Google Scholar, Cochrane Library, Clinical key, EBSCO publishing and Ovid, which had reported cardiovascular adverse events potentially caused by regorafenib were absorbed. Data of clinical characteristics and cardiovascular events including hypertension, hemorrhage, thrombosis, and heart failure were extracted from selected literatures for the final analysis. Pooled analysis of cardiovascular adverse events was developed by relative risks (RRs) and corresponding 95% confidence intervals (CIs) with software STATA 13.0 and RevMan 5.3.

Results

Thirty studies including 3813 patients were fit into analysis. The incidences of cardiovascular events of all-grade were: hypertension, 36.8% (95% CI, 29.8%-43.8%), hemorrhage, 8.6% (95% CI, 3.2%-14%), thrombosis, 1.4% (95% CI, 0.1%-2.8%), and heart failure, 2.9% (95% CI, 0.3%-5.6%). The incidences of cardiovascular events of high-grade were: hypertension, 9.9% (95% CI, 7.4%-12.4%), hemorrhage, 1.2% (95% CI, 0.3%-2.2%), thrombosis, 1.6% (95% CI, 0.2%-3.4%), and heart failure, 2.9% (95% CI, 0.3%-5.6%). The RRs and their 95% CIs of all-grade cardiovascular events among patients treated with regorafenib were: hypertension, 4.10 (95% CI, 3.07-5.46; P?ConclusionThe present meta-analysis has demonstrated that regorafenib is associated with an increasing risk of hypertension at all-grade and high-grade, as well as hemorrhage at all-grade. Adequate awareness of cardiovascular adverse events of regorafenib should be established for clinicians.

SUBMITTER: Chen J

PROVIDER: S-EPMC6203579 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Risk of regorafenib-induced cardiovascular events in patients with solid tumors: A systematic review and meta-analysis.

Chen Jianxin J Wang Junhui J

Medicine 20181001 41

<h4>Background</h4>The present comparative meta-analysis was conducted to evaluate the cardiovascular events of regorafenib in patients with solid tumors.<h4>Methods</h4>Eligible studies from MEDLINE, Google Scholar, Cochrane Library, Clinical key, EBSCO publishing and Ovid, which had reported cardiovascular adverse events potentially caused by regorafenib were absorbed. Data of clinical characteristics and cardiovascular events including hypertension, hemorrhage, thrombosis, and heart failure w ...[more]

PMID: 30313066

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Dataset Information

Risk of regorafenib-induced cardiovascular events in patients with solid tumors: A systematic review and meta-analysis.

Background

Methods

Results

Publications

Risk of regorafenib-induced cardiovascular events in patients with solid tumors: A systematic review and meta-analysis.

Similar Datasets

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