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Loss of DNA polymerase ? induces cellular senescence.

ABSTRACT: We aim to establish that accelerated aging and premature cellular senescence seen in individuals with Down syndrome is related to reduced DNA polymerase?. We report here that primary fibroblasts from Down syndrome individuals exhibit greater SA-?-gal staining (fourfold increase, P?

SUBMITTER: Ahmed AA 

PROVIDER: S-EPMC6203593 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Loss of DNA polymerase β induces cellular senescence.

Ahmed Aqila A AA   Smoczer Cristine C   Pace Brianna B   Patterson David D   Cress Cabelof Diane D  

Environmental and molecular mutagenesis 20180703 7

We aim to establish that accelerated aging and premature cellular senescence seen in individuals with Down syndrome is related to reduced DNA polymeraseβ. We report here that primary fibroblasts from Down syndrome individuals exhibit greater SA-β-gal staining (fourfold increase, P < 0.001), increased p16 transcript abundance (threefold increase, P < 0.01), and reduced HMGB1 nuclear localization (1.5-fold lower, P < 0.01). We also find that DNA polymerase β expression is significantly reduced in  ...[more]

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