NADPH oxidase NOX4 is a glycolytic regulator through mROS-HIF1? axis in thyroid carcinomas.
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ABSTRACT:
SUBMITTER: Tang P
PROVIDER: S-EPMC6203707 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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NADPH oxidase NOX4 is a glycolytic regulator through mROS-HIF1α axis in thyroid carcinomas.
Tang Ping P Dang Hao H Huang Jie J Xu Tao T Yuan Ping P Hu Jun J Sheng Jian-Feng JF
Scientific reports 20181026 1
The function of the NAD(P)H oxidases (NOXs) family member NOX4 is to generate reactive oxygen species (ROS), however, the molecular function of NOX4 has not been fully studied and waiting to be clarified. To elucidate the function of endogenous Nox4 in human thyroid carcinomas, papillomatosis thyroid cancer cells were used to study the cell growth by knocking down the expression of NOX4 and knocking out its functional partner p22phox/CYBA. As a result, the increasement of mitochondrial ROS(mROS) ...[more]
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