Ontology highlight
ABSTRACT:
SUBMITTER: Jarver P
PROVIDER: S-EPMC6203749 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20181026 1
Recognition of nucleic acids by endosomal Toll-like receptors (TLR) is essential to combat pathogens, but requires strict control to limit inflammatory responses. The mechanisms governing this tight regulation are unclear. We found that single-stranded oligonucleotides (ssON) inhibit endocytic pathways used by cargo destined for TLR3/4/7 signaling endosomes. Both ssDNA and ssRNA conferred the endocytic inhibition, it was concentration dependent, and required a certain ssON length. The ssON-media ...[more]