Ontology highlight
ABSTRACT:
SUBMITTER: Belarif L
PROVIDER: S-EPMC6203796 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Belarif Lyssia L Mary Caroline C Jacquemont Lola L Mai Hoa Le HL Danger Richard R Hervouet Jeremy J Minault David D Thepenier Virginie V Nerrière-Daguin Veronique V Nguyen Elisabeth E Pengam Sabrina S Largy Eric E Delobel Arnaud A Martinet Bernard B Le Bas-Bernardet Stéphanie S Brouard Sophie S Soulillou Jean-Paul JP Degauque Nicolas N Blancho Gilles G Vanhove Bernard B Poirier Nicolas N
Nature communications 20181026 1
Targeting the expansion of pathogenic memory immune cells is a promising therapeutic strategy to prevent chronic autoimmune attacks. Here we investigate the therapeutic efficacy and mechanism of new anti-human IL-7Rα monoclonal antibodies (mAb) in non-human primates and show that, depending on the target epitope, a single injection of antagonistic anti-IL-7Rα mAbs induces a long-term control of skin inflammation despite repeated antigen challenges in presensitized monkeys. No modification in T c ...[more]