Ontology highlight
ABSTRACT:
SUBMITTER: Cheng CT
PROVIDER: S-EPMC6203837 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cheng Chun-Ting CT Qi Yue Y Wang Yi-Chang YC Chi Kevin K KK Chung Yiyin Y Ouyang Ching C Chen Yun-Ru YR Oh Myung Eun ME Sheng Xiangpeng X Tang Yulong Y Liu Yun-Ru YR Lin H Helen HH Kuo Ching-Ying CY Schones Dustin D Vidal Christina M CM Chu Jenny C-Y JC Wang Hung-Jung HJ Chen Yu-Han YH Miller Kyle M KM Chu Peiguo P Yen Yun Y Jiang Lei L Kung Hsing-Jien HJ Ann David K DK
Communications biology 20181026
Defective arginine synthesis, due to the silencing of <i>argininosuccinate synthase 1</i> (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeutic strategies. Here we show that depletion of extracellular arginine in arginine-auxotrophic cancer cells causes mitochondrial distress and transcriptional reprogramming. Mechanistically, argi ...[more]