Ontology highlight
ABSTRACT:
SUBMITTER: Vaynberg J
PROVIDER: S-EPMC6203859 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Vaynberg Julia J Fukuda Koichi K Lu Fan F Bialkowska Katarzyna K Chen Yinghua Y Plow Edward F EF Qin Jun J
Nature communications 20181026 1
Dynamic communication between integrin-containing complexes (focal adhesions, FAs) and actin filaments is critical for regulating cell adhesion. Pseudokinase ILK plays a key role in this process but the underlying mechanism remains highly elusive. Here we show that by recruiting FA adaptors PINCH and Parvin into a heterotrimeric complex (IPP), ILK triggers F-actin filament bundling - a process known to generate force/mechanical signal to promote cytoskeleton reassembly and dynamic cell adhesion. ...[more]