Ontology highlight
ABSTRACT:
SUBMITTER: Altieri AS
PROVIDER: S-EPMC6204406 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Altieri Amanda S AS Kelman Zvi Z
Frontiers in molecular biosciences 20181022
Chromosomal DNA replication is achieved by an assembly of multi-protein complexes at the replication fork. DNA sliding clamps play an important role in this assembly and are essential for cell viability. Inhibitors of bacterial (β-clamp) and eukaryal DNA clamps, proliferating cell nuclear antigen (PCNA), have been explored for use as antibacterial and anti-cancer drugs, respectively. Inhibitors for bacterial β-clamps include modified peptides, small molecule inhibitors, natural products, and mod ...[more]