Increased basal ganglia binding of ¹⁸ F-AV-1451 in patients with progressive supranuclear palsy.

ABSTRACT:

Background

Progressive supranuclear palsy (PSP) is difficult to diagnose accurately. The recently developed tau PET tracers may improve the diagnostic work-up of PSP.

Methods

Regional tau accumulation was studied using ¹⁸ F-AV-1451 PET in 11 patients with PSP and 11 age-matched healthy controls in the Swedish BioFinder study.

Results

¹⁸ F-AV-1451 standard uptake volume ratios were significantly higher in the basal ganglia in PSP patients when compared with controls (globus pallidus 1.75 vs 1.50; putamen 1.51 vs 1.35). Retention in the basal ganglia was correlated with age in both groups (r = .43-.78, P < .05). In PSP, we observed a significant correlation between clinical deterioration measured with the PSP rating scale and standard uptake volume

SUBMITTER: Smith R 

PROVIDER: S-EPMC6204612 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature