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Data on effects, tolerability and safety of Omega-3 Fatty Acids in Enteral Nutrition in the Critically ill.

ABSTRACT: In addition to the data reported in our systematic review and meta-analysis 'Current Evidence on Omega-3 Fatty Acids in Enteral Nutrition in the Critically ill' we present data on intensive care unit and hospital mortality, age distribution between included studies, tolerability and adverse events of enteral omega-3 supplementation compared with control interventions in the critically ill. Moreover, we report additional analyses on 28-day mortality comparing old versus new studies and high versus low quality trials. Finally, we report baseline and follow-up levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reported in the trials included in Koekkoek et al. (2018). For further interpretation and discussion we recommend reading our systematic review and meta-analysis Current Evidence on Omega-3 Fatty Acids in Enteral Nutrition in the Critically ill'.

SUBMITTER: Koekkoek WAC

PROVIDER: S-EPMC6205069 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Data on effects, tolerability and safety of Omega-3 Fatty Acids in Enteral Nutrition in the Critically ill.

Koekkoek W A C WAC Panteleon V V van Zanten A R H ARH

Data in brief 20181012

In addition to the data reported in our systematic review and meta-analysis 'Current Evidence on Omega-3 Fatty Acids in Enteral Nutrition in the Critically ill' we present data on intensive care unit and hospital mortality, age distribution between included studies, tolerability and adverse events of enteral omega-3 supplementation compared with control interventions in the critically ill. Moreover, we report additional analyses on 28-day mortality comparing old versus new studies and high versu ...[more]

PMID: 30666310

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Project description:To evaluate the impact of implementing an enteral nutrition algorithm on achieving optimal enteral nutrition delivery in the PICU.Prospective pre/post implementation audit of enteral nutrition practices.One 29-bed medical/surgical PICU in a freestanding, university-affiliated children's hospital.Consecutive patients admitted to the PICU over two 4-week periods pre and post implementation, with a stay of more than 24 hours who received enteral nutrition.Based on the results of our previous study, we developed and systematically implemented a stepwise, evidence and consensus-based algorithm for initiating, advancing, and maintaining enteral nutrition in critically ill children. Three months after implementation, we prospectively recorded clinical characteristics, nutrient delivery, enteral nutrition interruptions, parenteral nutrition use, and ability to reach energy goal in eligible children over a 4-week period. Clinical and nutritional variables were compared between the pre and postintervention cohorts. Time to achieving energy goal was analyzed using Kaplan-Meier statistical analysis.Eighty patients were eligible for this study and were compared to a cohort of 80 patients in the preimplementation audit. There were no significant differences in median age, gender, need for mechanical ventilation, time to initiating enteral nutrition, or use of postpyloric feeding between the two cohorts. We recorded a significant decrease in the number of avoidable episodes of enteral nutrition interruption (3 vs 51, p < 0.0001) and the prevalence and duration of parenteral nutrition dependence in patients with avoidable enteral nutrition interruptions in the postintervention cohort. Median time to reach energy goal decreased from 4 days to 1 day (p < 0.0001), with a higher proportion of patients reaching this goal (99% vs 61%, p = 0.01).The implementation of an enteral nutrition algorithm significantly improved enteral nutrition delivery and decreased reliance on parenteral nutrition in critically ill children. Energy intake goal was reached earlier in a higher proportion of patients.

Dataset Information

Data on effects, tolerability and safety of Omega-3 Fatty Acids in Enteral Nutrition in the Critically ill.

Publications

Data on effects, tolerability and safety of Omega-3 Fatty Acids in Enteral Nutrition in the Critically ill.

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